1. Hemorrhage (Bleeding)
Blood vessel gets injured by foreign matter, thick blood or pressure, and starts bleeding.

2. Hemostasis (White Thrombus)
Thrombocytes (blood platelets) and fibrinogens gather around the injured part and work together to stop the bleeding.

3. Coagulation (Red Thrombus)
After Hemostasis, fibrinogens in the blood are turned into fibrins by the effect of thrombin. Fibrin promotes hemostasis and treats the bleeding part.

4. Restoration
The vessel wall cells are multiplied and restored using fibrins as their footfold.

Lumbrokinase not only dissolves fibrin itself directly (as plasmin does) but also increases the amount of plasminogen activators (such as t-PA) in the blood stream.

5. Hemostasis (White Thrombus)
As soon as a fibrin mass is built, plasminogen in the blood is activated by plasminogen activators (t-PA & u-PA) supplied from the endothelial cells. Plasmin dissolves fibrin mass and breaks it down into FDP. t-PA: tissue plasminogen Activator u-PA: urokinase Plasminogen Activator FDP: Fibrin Degradation Products

6. Restoration
Those people with regular lumbrokinase administration are reported to have about 10 times more inactive t-PA than those without it. When excess fibrins appear in their vessels, inactive t-PA are activated, and immediately dissolve the fibrins.