CASE1

Disease: Mastocytoma

Female mixed-breed dog, 13 years old

Symptoms:A Mast cell tumor enlarged rapidly on the outside of the thigh. It was impossible to test her blood because the blood serum was sticky and thick.
15 days later, her blood serum became smooth and clear after administration of L-R Zyme.

CASE2

Disease:Hepatic function disorder

Female mixed-breed cat, 5 years old

Symptoms:Generalized jaundice due to a hepatic function disorder.
After 2 days, her generalized jaundice disappeared, and her appetite improved after the administration of L-R Zyme.

CASE3

Disease:Mitral regurgitation

Male Maltese, 13 years old

Symptoms:Insomnia; Cough

Concomitant medicine:He began to sleep well and stopped coughing from the 10th day of the administration of L-R Zyme.

CASE4

Disease:Diabetes; heart disease; Dementia

Male cat, 4 years old

Symptoms:Sudden difficulty in his gait, his front right limb was deathly cold.

Concomitant medicine:Lerite; Taurine
From the 7th day of administration of L-R Zyme, he was able to walk properly.

CASE5

Disease:The first stage of femoral artery thrombotic disease; heart disease

Male mixed-breed cat, 12 years old

Symptoms:He had difficulty rising to his feet. He seemed to lack energy and breathed a little quickly.
From the 3rd day of administration of L-R Zyme, he was able to walk properly and got his breath back. He also regained his vitality and appetite.

CASE6

Disease:Senile idiopathic vestibular function syndrome

Female German shepherd, 12 years old

Symptoms:Head inclination; lateral nystagmus; unsteady gait

Concomitant medicine:Antibiotic, Injections of Ringer's solution, Vitamins, Prednisolone
She regained her appetite on the day after five administrations of L-R Zyme. The lateral nystagmus subsided on the 3rd day. 20 days later, the head inclination had improved.

CASE7

Disease:Diabetic phlegmon

Female cat, 12 years old

Symptoms:Heat sensations; decreased appetite; dehydration; a blood-sugar level of 522;  a segment of  tissue had become necrotic

Concomitant medicine:Insulin
4 days after administration of L-R Zyme , her blood-sugar level went down from 522 to 230. She regained her appetite, and the progression of diabetic phlegmon had stopped.

CASE8

Disease:Heart failure

Male Yorkshire terrier, 8 years old

Symptoms:Dyspnea
About 3 days after the administration of 1/2  dose of L-R Zyme per day, he started to show signs of improvement. One week later, he completely recovered.

CASE9

Disease:Filariasis ; loss of  liver function

Male mixed-breed dog, 5 years old

Symptoms:Loss of appetite; accumulation of ascites in his abdomen, Anasarca of hind legs and inferior abdomen

Concomitant medicine:
Lasix, Spironolactone, Prazosin hydrochloride, Neophyllin, Urokinase, Glutathione200mg, Tagamet100mg
He improved slowly. His thrombus started to dissolve about 8 hours after the administration of L-R Zyme. However, it started to build up again after stopping the administration of L-R Zyme.

CASE10

Disease:Cardiomyopathy

Male mixed-breed cat, 15 years old

Symptoms:He suddenly writhed in agony and seemed to have difficulty breathing. He also had paralysis of the hind limbs.

Concomitant medicine:Persatin
He started to show signs of improvement on the 7th day of administration of L-R Zyme. Normal breathing returned, and he was able to walk properly in the 3rd week.

CASE11

Disease:Diabetes

Female mixed-breed cat, 17 years old

Symptoms:Dehydration; Dysphoria, infirmity; Tachycardia; Emesis, Ketonaemia; Metabolic acidosis.

Concomitant medicine:Insulin
She started to show signs of improvement on the 51st day after administration of L-R Zyme. Six months later, her blood-sugar level was down from 1000mg/dl to 83mg/dl.

CASE12

Disease:Dementia

Female Shiba dog(Japanese dog), 13 years old

Symptoms:Fecal incontinence, diminished hearing, slow response, occasional convulsion, difficulty in walking.

Concomitant medicine:Adrenal cortex hormone
From about the 10th day of administration of tablets of L-R Zyme, convulsions subsided and she walked easily.

CASE13

Disease:Diabetes mellitus

Female Shin Tzu, 8 years old

Concomitant medicine:Insulin
Three months later, the blood-sugar level went down form 300mg/dl to 130mg/dl. Her weight stopped decreasing. The amount of water intake and urination decreased.

CASE14

Disease:Liver disease

Female Shin Tzu, 8 years old

Symptoms:Lack of appetite; lack of energy; febricula; occasional emesis.　

Concomitant medicine:Liver strengthener He started to recover on the 20th day after administration of L-R Zyme.

CASE15

Disease:Hepatic lipidosis

Male mixed cat, 8 years old

Symptoms:Emesis

Concomitant medicine:Medicine for emesis
He recovered 5 days after administration of L-R Zyme.

CASE16

Disease:Heart failure

Male mixed-breed dog, 16 years old

Symptoms:Cough; unsteady gait

Concomitant medicine:Lasix, temocapril hydrochloride
He started to recover on the 4th or 5th day after administration of L-R Zyme. He was able to walk without staggering.

CASE17

Disease:Vestibular function failure

Male shih Tzu, 12 years old

Symptoms:Incline of his left ear; occasionally unsteady in the lower back; cross and up-and-down nystagmus; torticollis to the left side (deteriorated into the condition where his head inclined at almost a 90 degree angle).

Concomitant medicine:Prednisolone
He improved about a month after administration of L-R Zyme. About 1 1/2 months later, he recovered.

CASE18

Disease:Chronic renal failure

Female golden retriever, 3 years old

Concomitant medicine:Covalzin
She regained her appetite and vitality. Two months after administration of L-R Zyme, her renal function level(BUN Cre) was slightly improved.

CASE19

Disease:Posterior aorta thrombosis caused by hypertrophic cardiomyopathy

Male mixed-breed cat, 5 years old

Concomitant medicine:Urokinase, Heparin
The coldness in his hind leg improved from the 4th or 5th day after administration of L-R Zyme. He also slightly regained his appetite.

CASE20

Disease:Posterior aorta thrombosis caused by hypertrophic cardiomyopathy

Male mixed-breed cat, 6 years old

Concomitant medicine:Urokinase, Heparin
Coldness in his hind legs was improved from the 4th or 5th day after administration of L-R Zyme. The unsteady gait with his hind legs was improved about a month after administration.